Hormone therapy for locally advanced prostate cancer

04 April 2011

Recent research has reported a benefit for hormone therapy prior to receiving radiotherapy in men with locally advanced prostate cancer.

The study was a randomised controlled trial in which men were randomly assigned to receive androgen deprivation therapy (ADT) or no additional treatment, prior to receiving radiotherapy.

The study found that the men who received ADT had a 11.4% chance of dying from prostate cancer over the following ten years.  This compares to 22.0% amongst men who received radiotherapy alone. 

On this basis, we would expect ADT to prevent around one in ten deaths from prostate cancer after ten years.

Note that this highly significant finding is consistent with current guidelines for management of locally advanced prostate cancer.

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Page last edited: 02 October 2011